Integration of scATAC-Seq with scRNA-Seq Data.
Methods in molecular biology (Clifton, N.J.)(2023)
Abstract
Single-cell studies are enabling our understanding of the molecular processes of normal cell development and the onset of several pathologies. For instance, single-cell RNA sequencing (scRNA-Seq) measures the transcriptome-wide gene expression at a single-cell resolution, allowing for studying the heterogeneity among the cells of the same population and revealing complex and rare cell populations. On the other hand, single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-Seq) can be used to define transcriptional and epigenetic changes by analyzing the chromatin accessibility at the single-cell level. However, the integration of multi-omics data still remains one of the most difficult tasks in bioinformatics. In this chapter, we focus on the combination of scRNA-Seq and scATACSeq data to perform an integrative analysis of the single-cell transcriptome and chromatin accessibility of human fetal progenitors.
MoreTranslated text
Key words
Bioinformatics,Integrative analysis,Multi-omics,scATAC-seq,scRNA-seq
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined