TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids

Choon Leng So,Mélanie Robitaille,Gregory R Monteith

Cell Calcium（2023）

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摘要

•Cancer cells are subjected to physical stimuli.•Cells migrate faster at higher viscosity.•Higher viscosity results in Na+/H+ exchanger 1 (NHE1) polarization.•Activation of TRPV4 through NHE1-induced cell swelling promotes cell migration.•Ca2+ signaling pathways have roles in cancer cell migration.

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关键词

TRPV4,TRPM7,Cancer, Cell migration,Epithelial-mesenchymal transition

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