Endocrine system involvement in patients with RASopathies: A case series.

M A Siano,R Pivonello,M Salerno, M Falco, C Mauro,D De Brasi, A Klain, S Sestito,A De Luca,V Pinna, C Simeoli,D Concolino,Ciro Gabriele Mainolfi,T Mannarino,P Strisciuglio, M Tartaglia,D Melis

Frontiers in endocrinology（2022）

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摘要

The collected data demonstrate a high prevalence of thyroid autoimmunity, confirming an increased risk to develop autoimmune disorders both in NS and CFCS. Reduced BMD, probably associated to reduced physical activity and inflammatory cytokines, also occurs. These findings are expected to have implications for the follow-up and prevention of osteopenia/osteoporosis in both NS and CFCS.

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关键词

CFC,RASopathies,autoimmunity,bone mineral density,vitamin D

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