Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.

Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau,Aleix Ribas-Latre,Claudia Gebhardt,Lisa Roth,Kerstin Krause,Kathrin Landgraf,Antje Körner,Kerstin Rohde-Zimmermann,Anne Hoffmann,Nora Klöting,Adhideb Ghosh,Wenfei Sun,Hua Dong,Christian Wolfrum,Tienush Rassaf,Ulrike B Hendgen-Cotta,Michael Stumvoll,Matthias Blüher,John T Heiker,Juliane Weiner

Clinical and translational medicine（2022）

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摘要

These data demonstrate for the first time a functional relevance of MBs lipid binding properties and establish MB as an important regulatory element of thermogenic capacity in brown and likely beige adipocytes.

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关键词

energy expenditure,hemoprotein,metabolism,obesity,oxphos,uncoupling protein 1

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