Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors.

Fanfan Li,Shuping Zhao,Cheng Wei, Yaodi Hu, Tianlong Xu, Xueyi Xin, Tingwei Zhu, Liting Shang, Shanwen Ke, Jiang Zhou,Xiaojun Xu, Yue Gao,Ai Zhao,Jimin Gao

Frontiers in immunology（2022）

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摘要

These findings showed that Nectin4-7.19 CAR-T cells had potential therapeutic efficacy and exerted a synergistic role with FAP-12 CAR-T cells, further demonstrating that Nectin4 and FAP were able to serve as promising targets for safe and effective CAR-T therapy of malignant solid tumors.

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关键词

CCL19,cancer-associated fibroblasts,chimeric antigen receptor T cell,fibroblast activation protein,interleukin-12,interleukin-7,malignant solid tumors,nectin cell adhesion molecule-4

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