X-ray-irradiated K562 feeder cells for expansion of functional CAR-T cells

Khac Cuong Bui, Viet Hoanh Ho, Hien Hanh Nguyen,Thanh Chung Dang, Thu Hang Ngo,Thi Mai Ly Nguyen,Linh Toan Nguyen, Thuy Linh Dang,Thanh Tung Tran, Quang Hoa Le, Hong Lam Pham, Van Ba Nguyen,Van Mao Can

Biochemistry and Biophysics Reports（2023）

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摘要

Immunotherapy, particularly CAR-T therapy has recently emerged as an innovator for cancer treatment. Gamma-irradiated K562 cells is a common and effective method to stimulated CAR-T cells prior to treatment. However, high cost and limited equipment of gamma-irradiation is drawback of this method. This requires the establishment of CAR-T-expanding alternatives, such as X-ray-irradiated K562 cells.

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关键词

X-ray irradiation,CAR-T immunotherapy,K562 feeder cells

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