The sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors.

British journal of pharmacology（2023）

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摘要

Sigma-1 antagonism harnesses endogenous opioids produced by TRPV1+ neurons to reduce hyperalgesia by increasing μ receptor activity.

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关键词

Sigma-1 receptors,TRPV1,endomorphin-2,resiniferatoxin,μ-opioid receptors

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