Concentrations of dexmedetomidine and effect on biomarkers of cartilage toxicity following intra-articular administration in horses.
American journal of veterinary research（2022）
Abstract
Systemic concentrations of dexmedetomidine remained low, compared to synovial fluid concentrations. CS846, a marker of articular cartilage synthesis, increased in a dose-dependent fashion. Based on these findings, further dose titration and investigation of analgesic and adverse effects are warranted.
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