Enzyme-induced morphological transformation of self-assembled peptide nanovehicles potentiates intratumoral aggregation and inhibits tumour immunosuppression

Juanjuan Cao,Xiaoying Liu,Xiaomeng Yuan,Fanhu Meng,Xinyu Sun,Lingzhi Xu,Hongjie Li,Yun Liu,Zexin Hong,Jingkun Bai

Chemical Engineering Journal（2023）

引用 7|浏览10

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摘要

•DOX/IpYR achieved high penetration and long-term retention simultaneously.•DOX/IpYR regulated the expression of immune factors and PD-L1.•DOX/IpYR suppressed tumour growth and metastases.

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关键词

Morphology transformation,Self-assembling peptides,Intracellular retention,Immune regulation,Alkaline phosphatase

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