Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection.

Lloyd Tanner,Jesper Bergwik,Ravi K V Bhongir,Manoj Puthia,Pernilla Lång,Mohamad N Ali,Charlotte Welinder,Patrik Önnerfjord,Jonas S Erjefält,Lena Palmberg,Göran Andersson,Arne Egesten

Frontiers in immunology（2022）

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摘要

Taken together, the findings of this study suggest a key role for TRAP5 in modulating airway inflammation. This could have bearing in diseases such as CF and COPD where excessive neutrophilic inflammation could be targeted by pharmacological inhibitors of TRAP5.

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关键词

NF-κB,Pseudomonas aeruginosa,SPP1/OPN,TRAP5/ACP5,cystic fibrosis,immune cell recruitment

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