Enzymes of Fibrosis in Chronic Liver Disease.

Ioannis Tsomidis,George Notas,Costas Xidakis,Argyro Voumvouraki,Dimitrios N Samonakis,Mairi Koulentaki,Elias Kouroumalis

Biomedicines（2022）

引用 5|浏览19

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摘要

(1) There is evidence that collagen synthesis increases in the early stages of PBC, but the collagenolytic mechanism may compensate for the increased synthesis. (2) In viral disease, fibrosis may be due to decreased degradation rather than increased synthesis. (3) The final biochemical stages of liver fibrosis may be quantitatively different according to underlying etiology.

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关键词

collagen turnover,matrix metalloproteinases,primary biliary cholangitis,prolyl hydroxylase

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