Outbreak of carbapenem-resistant enterobacteria in a thoracic-oncology unit through clonal and plasmid-mediated transmission of the bla OXA-48 gene in Southern France.

Linda Hadjadj,Nadim Cassir,Nadia Saïdani, Clémence Hoffman,Philippe Brouqui, Philippe Astoul,Jean-Marc Rolain,Sophie Alexandra Baron

Frontiers in Cellular and Infection Microbiology（2022）

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摘要

WGS demonstrated the dissemination of the gene by both clonal ( ST22 and ST1007) and plasmid spread (pOXA-48 IncL/M). The origin of this outbreak appeared to be both external and internal to the ward. This evidence of cross-infection supports the urgent need for the implementation of infection control measures to prevent CPE dissemination.

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关键词

IncL/M plasmid,blaOXA-48 gene,carbapenemase,fecal microbiota transplantation,whole genome sequencing

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