A Promising Target of Langchuangding Prescription Treating Systemic Lupus Erythaematosus Integrated Network Pharmacology with HPLC-MS and Molecular Docking.

Qianqian Li,Jing Sun,Jifang Tu,Haichang Li,Jida Zhang,Huanpeng Gu,Zhijun Xie,Huiqing Lv

Frontiers in bioscience (Landmark edition)（2022）

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摘要

The results showed that LCD could relieve SLE, which might be attributed to inducing the activated T cells apoptosis by up-regulating CASP3 expression levels. The network pharmacology and molecular docking approach provide a new insight for deepening understanding about TCM. LCD potentially represents a promising therapeutic prescription for SLE supplement treatment with no adverse effects.

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关键词

HPLC-MS,Langchuangding prescription,T cell apoptosis,network pharmacology,systemic lupus erythaematosus,target

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