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Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.

Qian Xiao,Zhineng Kang,Canwen Liu,Biao Tang

Frontiers in bioscience (Landmark edition)（2022）

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Abstract
In conclusion, PNS could promote mitophagy via the PINK1/Parkin pathway by inhibiting activation of the NLRP3 inflammasome, alleviating cerebral I/R injury in rats.
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Key words
NLRP3 inflammasome,PINK1, saponins,Parkin,cerebral ischemia-reperfusion,mitophagy
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