The dual role of CD70 in B-cell lymphomagenesis.
Clinical and translational medicine（2022）
摘要
Our findings suggest that CD70 can play a role in either tumour suppression or oncogenesis in DLBCL, likely via distinct immune evasion mechanisms, that is, impairing T cell priming or inducing T cell exhaustion. Characterisation of specific dysfunction of CD70 in DLBCL may thus provide opportunities for the development of novel targeted immuno-therapeutic strategies.
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关键词
CD70,HBV infection,diffuse large B-cell lymphoma,genetic aberration,immune evasion
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