Evaluation of characteristic metabolites of aromatic amino acids in patients with HIV infection at different stages of disease.
Journal of clinical laboratory analysis(2023)
Abstract
The developed method can be used for rapid and sensitive quantification of the AAA metabolism profile in vivo to further appraise the process of HIV infection, evaluate intervening measures, conduct mechanistic investigations, and further study the utility of PAGln, a characteristic metabolite of AAA, as a biomarker of HIV infection coupled with metabolic syndrome.
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Key words
aromatic amino acid metabolites,high-performance liquid chromatography-tandem mass spectrometry,human immunodeficiency virus,metabolic disorder,phenylacetylglutamine
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