Prolonged Lifetimes of Histologic Autofluorescence in Ectopic Retinal Pigment Epithelium in Age-Related Macular Degeneration.

Rowena Simon, Marius Jentsch, Parva Karimimousivandi,Dongfeng Cao,Jeffrey D Messinger,Daniel Meller,Christine A Curcio,Martin Hammer

Investigative ophthalmology & visual science（2022）

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摘要

In the process of RPE degeneration, comprising different steps of dysmorphia and migration, lengthening of autofluorescence lifetimes and a hypsochromic shift of emission spectra can be observed. These autofluorescence changes might provide early biomarkers for AMD progression and contribute to our understanding of RPE-driven pathology.

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关键词

age-related macular degeneration (AMD),retinal pigment epithelium (RPE),fundus autofluorescence (FAF),fluorescence lifetime,fluorescence spectra,atrophy,migration

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