Practical Guide for Radiological Diagnosis of Primary and Secondary Sclerosing Cholangitis

Sclerosing cholangitis comprises a group of conditions that lead to chronic cholestatic dis-ease of the bile ducts, characterized by inflammation, fibrosis, and segmental strictures of the intrahepatic and/or extrahepatic ducts, and can be classified as primary sclerosing chol-angitis or secondary sclerosing cholangitis. In this review, we follow a logical step-by-step appraisal of the clinical and radiological findings of the main secondary sclerosing cholangi-tis groups, finally arriving at the exclusion diagnosis, which is primary sclerosing cholangi-tis. At the end, a practical guide is provided, aiming to facilitate the radiological approach to this complex group of diseases.Semin Ultrasound CT MRI 43:490-509 (c) 2022 Elsevier Inc. All rights reserved.