A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice.

Qianqian Ma,Xiaozhi Hu,Fangyu Liu,Zhonglian Cao,Lei Han, Kaicheng Zhou, Yu Bai,Yuting Zhang,Yanyang Nan,Qianying Lv,Jia Rao,Tao Wu,Xue Yang,Haidong He,Dianwen Ju,Hong Xu

Frontiers in immunology（2022）

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摘要

Collectively, anti-ANGPTL3/IL22 bifunctional fusion protein can be a promising novel therapeutic strategy for DN by reducing podocyte injury, ameliorating inflammatory response, and enhancing renal tissue recovery.

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关键词

angiopoietin-like protein 3,diabetic nephropathy,diabetic nephropathy DN,fusion protein,inflammatory response,interleukin-22,podocyte injury

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