Proteomic Analysis of Hepatic Fibrosis in Human Immunodeficiency Virus-Associated Nonalcoholic Fatty Liver Disease Demonstrates Up-regulation of Immune Response and Tissue Repair Pathways.

Lindsay T Fourman,Takara L Stanley,Mollie W Ockene,Colin M McClure,Mabel Toribio,Kathleen E Corey,Raymond T Chung,Martin Torriani,David E Kleiner,Colleen M Hadigan,Steven K Grinspoon

The Journal of infectious diseases（2023）

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摘要

Among individuals with HIV-associated NAFLD, hepatic fibrosis was associated with a distinct proteomic signature involving up-regulation of tissue repair and immune response pathways. These findings enhance our understanding of potential mechanisms and biomarkers of hepatic fibrosis in HIV.

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关键词

HIV,NAFLD,hepatic fibrosis,proteomics,visceral adipose tissue

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