LncRNA-WAKMAR2 regulates expression of CLDN1 to affect skin barrier through recruiting c-Fos.

Yunhua Tu,Li Wang,Xiaoli Wang,Wenjuan Wu,Ying Tu,Dandan Zou, Yuanyuan Deng,Jue Qi,Can Cao,Dan Xu,Yanjie Chai,Yun Zhu, Juan Zhang,Jun Sun,Fan Lai,Li He

Contact dermatitis（2022）

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摘要

We identified a crucial LncRNA (WAKMAR2) for the protection of the skin barrier in vitro and in vivo. Mechanically, it can specifically interact with c-Fos protein for the regulation of CLDN1, a finding which could be applied for CAD treatment.

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关键词

CLDN1,Chronic actinic dermatitis,WAKMAR2,c-Fos,skin barrier

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