In-vitro anti-Mycobacterium tuberculosis effect of Eugenol
Indian Journal of Tuberculosis(2022)
摘要
Background/Objectives
Mycobacterium tuberculosis, the causative agent of tuberculosis has developed resistance to most of the available antimicrobials. Therefore research on the detection of new antimicrobials against Mycobacterium tuberculosis is needed urgently. Essential oils extracted from plants have been shown to have anti-Mycobacterium tuberculosis effect in in-vitro experiments. Essential oil contains many chemicals and any one or more than one chemical may have the anti-Mycobacterium tuberculosis effect. Eugenol is one such chemical in the essential oil and the anti-Mycobacterium tuberculosis effect of eugenol is investigated.
Methods
The anti-Mycobacterium tuberculosis effect of eugenol was evaluated against H37Rv and twelve clinical isolates of Mycobacterium tuberculosis in the BD BACTEC MGIT instrument using different volumes of eugenol.
Results
H37Rv and all the twelve clinical isolates of Mycobacterium tuberculosis were inhibited by eugenol. The minimal inhibitory concentration of H37Rv was 2.5 μl (2.67 mg) and those of the clinical isolates of Mycobacterium tuberculosis ranged from to 2.5 μl (2.67 mg) to 10 μl (10.68 mg).
Conclusion
Eugenol has anti-Mycobacterium tuberculosis effect in the in-vitro BD BACTEC MGIT method.
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关键词
Anti-M.tuberculosis,BD BACTEC MGIT method,Eugenol,H37Rv,Isoniazid,Rifampicin,MIC,Multidrug resistant
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