Influenza incidence and air pollution: Findings from a four-year surveillance study of prefecture-level cities in China.

The influenza incidence showed a strong spatial correlation and associated sensitivity to changes in concentrations of air pollutants. Hypersensitive areas were mainly located in the southeastern part of northeastern China, the coastal areas of the Yellow River Basin, the Beijing-Tianjin-Hebei region and surrounding areas, and the Yangtze River Delta. The influenza incidence was most sensitive to CO, NO, and SO, with the occurrence of influenza being most likely in areas with elevated concentrations of these three pollutants. Therefore, the formulation of targeted influenza prevention and control strategies tailored for hypersensitive, medium-sensitive, low-sensitive, and insensitive areas are urgently needed.