Wireless Monitoring of Small Molecules on a Freely-Moving Animal using Electrochemical Aptamer Biosensors

This paper presents a wireless electrochemical sensing system for in vivo small-molecule sensing with structure-switching aptamers. A 65-nm CMOS electrochemical sensing circuit with an on-chip waveform generator is integrated with a Bluetooth microcontroller and battery for robust wireless recording. The device performs data acquisition every 10 seconds and consume an average current of 3mA after duty-cycling. Real-time sensing of infused antibiotics (kanamycin) concentration in the interstitial fluids (ISF) are demonstrated on a freely-moving animal.