Tropoelastin Improves Post-Infarct Cardiac Function.
Circulation Research(2023)
Abstract
We demonstrate for the first time that purified human tropoelastin can significantly repair the infarcted heart in a rodent model of MI and that human cardiac fibroblast synthesize elastin. Since human cardiac fibroblasts are primarily responsible for post-MI scar synthesis, our findings suggest exciting future clinical translation options designed to therapeutically manipulate this synthesis.
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Key words
collagen,echocardiography,elastin,heart,myocardial infarction,therapeutics,tropoelastin
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