Cobalt-Catalyzed Nitrogen Atom Insertion in Arylcycloalkenes
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY(2022)
摘要
Developing strategies enabling the modification of underlying molecular frameworks facilitates access to underexplored chemical spaces. Skeletal editing is an emerging technology for late-stage diversification of bioactive molecules. However, the current state of this knowledge remains undeveloped. This work describes a simple protocol that "inserts" a nitrogen atom into arylcycloalkenes to form the corresponding N-heterocycles. The use of an inexpensive cobalt catalyst under aqueous and open-air conditions makes this protocol very practical. Examples of late-stage modification of compounds of pharmaceutical interest and complex fused ring compounds further demonstrated the potentially broad applicability of this methodology.
更多查看译文
关键词
arylcycloalkenes,nitrogen,cobalt-catalyzed
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要