Analysis of inhibitors of the anoctamin-1 chloride channel (transmembrane member 16A, TMEM16A) reveals indirect mechanisms involving alterations in calcium signalling.

Michele Genovese, Martina Buccirossi,Daniela Guidone,Rossella De Cegli,Sergio Sarnataro,Diego di Bernardo,Luis J V Galietta

British journal of pharmacology（2023）

引用 8|浏览14

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摘要

Most TMEM16A inhibitors are endowed with indirect effects mediated by alteration of intracellular Ca handling, which may in part preclude their use as TMEM16A research tools.

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关键词

calcium signaling,chloride channel,inositol triphosphate receptor,purinergic receptor

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