Longitudinal decline of plasma neurofilament light levels after antiretroviral initiation in people living with HIV.

Enrico Ripamonti,Arvid Edén,Staffan Nilsson,Anders Sönnerborg,Henrik Zetterberg,Magnus Gisslén

Journal of internal medicine（2023）

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摘要

Plasma NfL is a sensitive biomarker to assess ongoing central nervous system injury in PWH. Plasma NfL concentrations decline relatively fast following ART initiation and then stabilize after 48 weeks. Plasma NfL concentrations are associated with CD4 count and stage of HIV disease. No correlations were seen with different ART regimens.

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关键词

ART,CD4+,HIV,cerebrospinal fluid NfL,neuronal injury,plasma NfL

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