Response to growth hormone treatment in patients with sufficient secretion

Background: There are situations of short stature, with a normal stimulus test for GH, but decreased nocturnal secretion in which there could be a benefit with GH treatment. Objetives: To assess adult height and height gain in patients with neurosecretory dysfunction diagnosis treated with growth hormone. Material y methods: Longitudinal, retrospective and observational study including 61 patients treated with growth hormone after diagnosis of neurosecretory dysfunction who have already reached adult height. Variables such as adult height gain, growth rate, growth prognosis variation and IGF-I and IGFBP-3 were evaluated. Variables related to a good response in the first year have also been calculated, using the Index of responsiveness (IoR). Results: GH treatment produces an improvement in growth rate and height, observing an increase in adult height with respect to initial height of 1.15 +/- 0.60 SD, height with respect to genetic height of -0.015 +/- 0.62 SD and adult height with respect to the initial growth prognosis 0,74 +/- 1,13 DE. The IoR in the first year is associated with a greater increase in height in the first year (p = 0.000), with a greater adult height (p = 0.000) and with a greater gain in adult height compared to its initial height (p = 0.039). Conclusions: Patients with growth delay due to neurosecretory dysfunction of GH show a good response to treatment with rhGH, observing a significant height gain in their genetic size and improving their initial growth prognosis. (c) 2022 SEEN and SED. Published by Elsevier Espana, S.L.U. All rights reserved.