Analysis of a panel of tmem16a chloride channel inhibitors reveals indirect mechanisms involving alteration of calcium signaling.

Michele Genovese, Martina Buccirossi,Daniela Guidone,Rossella De Cegli,Sergio Sarnataro,Diego di Bernardo,Luis J V Galietta

British journal of pharmacology（2022）

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摘要

Most TMEM16A inhibitors are endowed with indirect effects mediated by alteration of intracellular Ca handling, which may in part preclude their use as TMEM16A research tools.

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