Effects of an inhaled soluble guanylate cyclase (sGC) stimulator MK-5475 in pulmonary arterial hypertension (PAH)

Ednan K. Bajwa,Dawn Cislak,John Palcza,Hwa-ping Feng,Eric J. Messina,Tom Reynders, Jean-François Denef,Vasile Corcea,Eseng Lai,S. Aubrey Stoch

Respiratory Medicine（2022）

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摘要

•Current PAH therapies are administered systemically resulting in extrapulmonary effects.•MK-5475 is an inhaled sGC stimulator under development for the treatment of PAH.•This Phase 1 study evaluated single-dose MK-5475 in adult PAH participants.•Single inhaled doses of MK-5475 had favorable effects on pulmonary vasodilation.•Inhaled MK-5475 had a favorable safety profile without deleterious systemic effects.

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关键词

Pulmonary vascular resistance,Functional respiratory imaging,Dry-powder inhaler,Pulmonary blood volume,Pulmonary selectivity

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