The roles of NADPH and isocitrate dehydrogenase in cochlear mitochondrial antioxidant defense and aging
Hearing Research（2022）
摘要
•A growing body of evidence indicates a role for mitochondrial dysfunction in hearing loss.•The NADP+/NADPH couple is essential for maintaining cellular redox state and energy metabolism.•IDH2 is thought to be the main supplier of NADPH for the mitochondrial antioxidant defense system.•IDH2 may play a key role in maintenance of cochlear mitochondrial antioxidant defenses
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关键词
inner ear,cochlea,mitochondrial dysfunction,oxidative stress,isocitrate dehydrogenase,antioxidant defense
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