Superiority of ceftazidime off-label high-dose regimen in PK/PD target attainment during treatment of extensively drug-resistant Pseudomonas aeruginosa infections in cancer patients.

Alzbeta Zavrelova,Martin Sima,Jana Malakova,Petra Rozsivalova,Pavla Paterova,Pavel Zak,Benjamin Visek,Danica Michalickova,Ondrej Slanar,Jakub Radocha

British journal of clinical pharmacology（2023）

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摘要

We proved the superiority of the ceftazidime off-label high-dose regimen in PK/PD target attainment with very low occurrence of adverse effects. The off-label high-dose regimen should be used to optimize treatment of XDR P. aeruginosa infections.

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关键词

ceftazidime,dosing regimen,glomerular filtration rate,nonlinear mixed-effects modelling,pharmacokinetics

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