Inhibition of the JAK2/STAT3 pathway and cell cycle re-entry contribute to the protective effect of remote ischemic pre-conditioning of rat hindlimbs on cerebral ischemia/reperfusion injury.

Yongmei Zhao,Mao Ding,Feng Yan,Jie Yin,Wenjuan Shi, Nan Yang,Haiping Zhao,Yalan Fang,Yuyou Huang,Yangmin Zheng,Xueqi Yang,Wei Li,Xunming Ji,Yumin Luo

CNS neuroscience & therapeutics（2023）

引用 4|浏览25

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摘要

RIPC ameliorates the induction of the JAK2/STAT3 pathway and cell cycle regulators cyclin D1 and CDK6 by MCAO, and this net inhibition of cell cycle re-entry by RIPC is associated with downregulation of STAT3 phosphorylation.

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关键词

Janus-activated kinase 2/signal transducer and activator of transcription 3,cerebral ischemia/reperfusion,cyclin D1,cyclin-dependent kinases 6,remote ischemic pre-conditioning

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