Glabraquinone A and B, new bisanthraquinones from Prismatomeris glabra (Korth.) Valeton
NATURAL PRODUCT RESEARCH(2024)
Abstract
Two new bisanthraquinones, glabraquinone A and B (1-2) were isolated from the root of Prismatomeris glabra (Korth.) Valeton. In addition to the new glabraquinones, six known anthraquinones, that is, 1-hydroxy-2-methoxy-6-methylanthraquinone (3), 1,2-dimethoxy-7-methylanthraquinone (4), lucidin (5), nordamnacanthal (6), damnacanthal (7) and 2-carboxaldehyde-3-hydroxyanthraquinone (8)) and an aromatic compound, that is, catechol diethyl ether (9) were isolated and characterized in this study. Compounds 1, 4 and 9 showed mild activity, reducing N2A cell viability to 77%, 82% and 77%, respectively, in anti-neuroblastoma assay.
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Key words
Prismatomeris glabra (Korth,) Valeton,Rubiaceae,glabraquinones,bisanthraquinones,anthraquinones,anti-neuroblastoma
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