Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES(2023)
摘要
Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.
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关键词
exosome,genitourinary cancers,drug resistance
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