Roxadustat (FG-4592) protects against ischaemia-induced acute kidney injury via improving CD73 and decreasing AIM2 inflammasome activation.

Huan Yang,Yong Wu,Ming Cheng,Ming Zhang, Xiaoyan Qiu,Shaojun Liu,Minmin Zhang

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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摘要

FG-4592-conveyed protection against AKI might be mediated by the induction of CD73 and the suppression of the AIM2 inflammasome, which may provide a novel therapeutic method for the treatment of AKI.

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关键词

AIM2,CD73,HIF,inflammation,roxadustat

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