Resveratrol inhibits osteoporosis in mice model
MATERIALS EXPRESS(2022)
Abstract
Our study intends to assess whether resveratrol can ameliorate osteoporosis in mice. Ovariectomized (OVX) mice were established to measure SFRP1 level and SFRP1-siRNA was used to assess its effect on BMSCs osteogenesis. SFRP1 was significantly up-regulated in bone tissues and BMSCs of OVX mice with a gradual decrease during osteogenesis. However, it was not changed during BMSCs differentiation towards osteo-clasts. SFRP1 knockdown significantly increased mineralization potentiality, elevated ALP activity and upreg-ulated several osteoblast-specific genes. Moreover, bone loss was reduced in resveratrol-treated OVX mice, possibly through upregulating osteogenesis-associated genes and downregulating SFRP1. In conclusion, resveratrol ameliorates osteogenesis of BMSCs, implying that it might be utilized for treating PMOP.
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Key words
Resveratrol,Secreted Frizzled-Related Protein 1,Bone Marrow Mesenchymal Stem Cells,Marrow-Derived Macrophages,Postmenopausal Osteoporosis
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