Synthetic Strategies toward Higher Cocrystals of Some Resorcinols

Higher cocrystal synthesis depends on precise strategic approaches. A total of 32 stoichiometric ternary and quaternary cocrystals based on resorcinol derivatives were achieved using structural inequivalence and shape-size mimicry approaches and are reported here. Along with 28 binary precursors that were also obtained, these 60 cocrystals serve to generalize synthetic strategies toward these ends. A number of large synthon Aufbau modules (LSAMs) were designed depending on the substitution pattern in the resorcinol. The LSAMs from 5-substituted resorcinol were found to be useful in designing higher cocrystals. The construction of a stoichiometric quaternary cocrystal without the "special" compound 2,3,S,6-tetramethylpyrazine has been finally secured.