Use of whole genome sequencing to estimate the contribution of immune evasion and waning immunity on decreasing COVID-19 vaccine effectiveness.

Margaret L Lind,Richard Copin,Shane McCarthy,Andreas Coppi, Fred Warner,David Ferguson,Chelsea Duckwall,Ryan Borg,M Catherine Muenker,John Overton,Sara Hamon,Anbo Zhou,Derek At Cummings,Albert I Ko,Jennifer D Hamilton,Wade Schulz,Matt D T Hitchings

The Journal of infectious diseases（2022）

Cited 1|Views22

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Abstract

Both waning protection and variant-specific immune evasion contributed to the lower effectiveness. While VE estimates against calendar-period-classified infections mirrored those against WGS-classified infections, our analysis highlights the need for WGS when variants are co-circulating and misclassification is likely.

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Key words

COVID-19,Vaccine effectiveness,variant specific immune evasion,waning,whole genome sequencing

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