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N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy

Julia Krug, Gabriele Rodrian,Katja Petter,Hai Yang,Svetlana Khoziainova,Wei Guo,Alan Bénard,Susanne Merkel,Susan Gellert,Simone Maschauer, Monika Spermann,Maximilian Waldner,Peter Bailey,Christian Pilarsky,Andrea Liebl,Philipp Tripal,Jan Christoph,Elisabeth Naschberger,Roland Croner,Vera S. Schellerer

Gastroenterology（2023）

Cited 7|Views37
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Abstract
Interferon-γ-receptor protein stability and signaling are impaired in colorectal carcinoma cells through tumor-associated N-glycosylation defects, leading to acquired interferon-γ resistance and poor prognosis.
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Key words
Colon Cancer,Immune Evasion,IFNGR1
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