Single-cell RNA-sequencing combined with bulk RNA-sequencing analysis of peripheral blood reveals the characteristics and key immune cell genes of ulcerative colitis.
World journal of clinical cases（2022）
Abstract
Through scRNA-seq analysis, LASSO diagnostic model building and WGCNA, we identified RhoB, CTSD and ZYX as core genes of UC that are closely related to monocyte infiltration that may serve as diagnostic markers and molecular targets for UC therapeutic intervention.
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Key words
Bulk RNA-seq,Key genes,Peripheral blood,Single-cell RNA-seq,Ulcerative colitis
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