HLA-DRB1*1501 influences long-term disability progression and tissue damage on MRI in relapse-onset multiple sclerosis.

Wallace J Brownlee,Carmen Tur,Andreea Manole,Arman Eshaghi,Ferran Prados,Katherine A Miszkiel,Claudia Am Gandini Wheeler-Kingshott,Henry Houlden,Olga Ciccarelli

Multiple sclerosis (Houndmills, Basingstoke, England)（2023）

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摘要

These findings provide evidence that the allele plays a role in MS severity, as measured by long-term disability worsening and a greater extent of inflammatory disease activity and tissue loss. may provide useful information when considering prognosis and treatment decisions in early relapse-onset MS.

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关键词

Clinically isolated syndrome,genetics,multiple sclerosis,prognosis

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