Intranasal interferon-beta alleviates anxiety and depressive-like behaviors by modulating microglia polarization in an Alzheimer's disease model
Neuroscience Letters(2023)
摘要
•APP overexpression in the hippocampus induced anxiety-like behaviors in rats.•APP overexpression in the hippocampus induced depressive-like behaviors in rats.•Psychiatric symptoms were accompanied with changes in expression of M1/M2 markers.•IFNβ improved anxious/depressive-like behaviors in AD rats.•IFNβ shifted microglia phenotype from M1 to M2 in the hippocampus of AD rats.
更多查看译文
关键词
Interferon-beta,Anxiety,Depression,Microglia,Polarization,Alzheimer’s disease
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要