The androgen system across the menstrual cycle: Hormonal, (epi-)genetic and psychometric alterations

•Genetics, epigenetics and hormones build a triangle mutually influencing each other.•Testosterone, LH, subjective behavior and methylation of the androgen receptor are measured over the menstrual cycle.•A significant increase of LH and testosterone plasma levels during the pre-ovulatory phase as well as a decrease of methylation of the androgen receptor at mid-luteal phase was observed.•Subjective ratings of physical condition and sexual interest peaked during the pre-ovulatory phase.•Physical condition correlated negatively with the androgen receptor gene methylation level.