ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice.
Arteriosclerosis, thrombosis, and vascular biology（2023）
Abstract
Our results suggest that an impaired collateral remodeling and sprouting angiogenesis in T2DM mice is associated with persistent IFN-I response in ECs and Mϕs. Dampening persistent inflammation and skewing ECs and Mϕ phenotype toward less inflammatory ones using rHDL nanotherapy may serve as a potential therapeutic target for T2DM peripheral arterial disease.
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Key words
diabetes mellitus, type 2,macrophages,neovascularization, physiologic,peripheral arterial disease,sequence analysis, RNA
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