Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort.

Farida S Akhtari,Dillon Lloyd,Adam Burkholder, Xiaoran Tong,John S House,Eunice Y Lee,John Buse,Shepherd H Schurman,David C Fargo,Charles P Schmitt,Janet Hall,Alison A Motsinger-Reif

Diabetes care（2022）

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摘要

Our findings in a multiancestry cohort elucidate how type 2 diabetes odds can be attributed to clinical, genetic, and environmental factors and emphasize the need for exposome data in disease-risk association studies. Race-based differences in predictive scores highlight the need for genetic and exposome-wide studies in diverse populations.

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diabetes,assessment,questionnaire-based

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