A Single-Cell Atlas Identifies Pretreatment Features of Primary Imatinib Resistance in Chronic Myeloid Leukemia

Vaidehi Krishnan,Florian Schmidt,Zahid Nawaz,Kian Leong Lee,Prasanna Nori Venkatesh, Meera Makheja, Zhu En Chan, Mengge Yu,Nirmala Arul Rayan,Michelle Gek Liang Lim,Alice Cheung,Sudipto Bari,John Ouyang,Owen Rackham,Tuan Zea Tan,William YK Hwang,Charles Chuah,Shyam Prabhakar,Sin Tiong Ong

Blood（2022）

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摘要

•A high-resolution single-cell map of diagnostic CML bone marrow to annotate features of TKI resistance.•Gene expression signatures within the LSCs and NK cells are indicative of TKI response.

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关键词

primary imatinib resistance,chronic myeloid leukemia,single-cell

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