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Perturbations in common and distinct inflammatory pathways associated with morning and evening fatigue in outpatients receiving chemotherapy.

Kord M Kober,Carolyn Harris,Yvette P Conley,Anand Dhruva,Vasuda Dokiparthi,Marilyn J Hammer,Jon D Levine,Kate Oppegaard,Steven Paul,Joosun Shin, Anatol Sucher,Fay Wright, Brian Yuen,Adam B Olshen,Christine Miaskowski

Cancer medicine（2023）

Cited 4|Views66
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Abstract
This study describes perturbations in common and distinct inflammatory pathways associated with morning and/or evening fatigue. PI3K-Akt was identified as a bottleneck pathway. The analysis identified potential targets for therapeutic interventions for this common and devastating clinical problem.
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Key words
cancer,chemotherapy,cytokines,fatigue,gene expression,inflammation,knowledge network,pathway impact analysis
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