CCL2-targeted ginkgolic acid exerts anti-glioblastoma effects by inhibiting the JAK3-STAT1/PI3K-AKT signaling pathway

Xi Chen,Mingwei Zhu,Xiaomeng Zou,Yingxuan Mao,Jiamei Niu,Jian Jiang,Tianxiu Dong, Ying Shi,Xiuhua Yang,Pengfei Liu

Life Sciences（2022）

引用 2|浏览4

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摘要

GA inhibits the progression of GBM cells by targeting CCL2, affecting the JAK-STAT and PI3K-AKT signaling pathways, and inhibiting the EMT regulators Snail and Slug. The outstanding antitumor properties of GA provide a novel strategy for the GBM therapy.

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关键词

Glioblastoma,Ginkgolic acid,CCL2,JAK3-STAT1/PI3K-AKT,Signaling pathway

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